DNA repair may be one thing that affects lifespan (see main story) – and centenarians can offer clues to others. Until she died on 19 August 2024, aged 117 years and 168 days, María Branyas Morera, of Spain, was officially the world’s oldest person.
When she was 116, a team of researchers collected blood, saliva and stool samples to analyse her genetics, microbiome and lifestyle.
Morera, who showed no sign of dementia, had many gene variants that keep blood lipid levels low, protecting the heart and cognition.
Blood test results also revealed her lipid metabolism was among the most efficient ever reported.
Team member Manel Esteller at the Josep Carreras Leukaemia Research Institute in Barcelona, Spain, says Morera didn’t drink alcohol or smoke, and adhered to a Mediterranean diet. She…